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- The CANHEART ‘big data’ research initiative is aimed at measuring and improving cardiovascular health and the quality of ambulatory cardiovascular care provided in Ontario, Canada using the population-based CANHEART cohorts. The CANHEART cohorts were created through the linkage of 19+ routinely collected health administrative, vital statistics, survey and laboratory databases housed at ICES. The strength of these cohorts lies in the large sample size, containing information on 9.8 million Ontarians age 20-105 years, and diversity of the linked databases. Building upon the insights gained to date through the CANHEART work, we have recently launched a new CANHEART SPOR project aimed at leveraging big data to conduct innovative cardiovascular clinical trials. We aim to: 1) undertake a pragmatic cluster randomized registry-based clinical trial to improve lipid-management amongst intermediate-and high-risk patients residing in high-risk health regions in Ontario (called CHOICES), and 2) develop novel algorithms for measuring clinical outcomes in clinical trials using health-related databases and compare whether they are as accurate as traditional event ascertainment methods in a prospective clinical trial (called INVESTED). These projects will be undertaken by an interdisciplinary team consisting of experts in administrative health databases, implementation science, clinical trials, knowledge translation and patient engagement.
- Researcher Paula Byrne writes on what she and her colleagues learned from a meta-analysis of 21 clinical trials involving 140,000 patients. Our study highlights that patients and doctors need to be supported to make decisions about treatments using evidence from all available studies and presented in a format that helps them understand potential benefits.
- Tutorial that I did to learn R. Contribute to yukikongju/R-Tutorial development by creating an account on GitHub.
- This article recommends 33 free books which will teach you the basics of R, how to produce amazing plots, how to apply R to lots of disciplines, and how to efficiently program in R.
- The bookdown package is an open-source R package that facilitates writing books and long-form articles/reports with R Markdown.
- This book will teach you how to do data science with R: You’ll learn how to get your data into R, get it into the most useful structure, transform it, visualise it and model it. In this book, you will find a practicum of skills for data science. Just as a chemist learns how to clean test tubes and stock a lab, you’ll learn how to clean data and draw plots—and many other things besides. These are the skills that allow data science to happen, and here you will find the best practices for doing each of these things with R. You’ll learn how to use the grammar of graphics, literate programming, and reproducible research to save time. You’ll also learn how to manage cognitive resources to facilitate discoveries when wrangling, visualising, and exploring data.
- El Objetivo del paquete aprendeR es facilitar que nuevas personas puedan R moderno con una curva de aprendizaje baja, y evitando que el inglés sea una barrera para que se puedan centrar en el aprendizaje competencial de R. Se incluyen traducciones al castellano de tutoriales presentes en otros paquetes (learnr, tutorial.helpers, r4ds.tutorials, ...), y eventualmente nuevos tutoriales más adelante.
- Reports in VigiBase, the WHO global database of individual case safety reports, often concern multi-drug users at risk of drug-drug interactions, and should be valuable for finding interaction signals. A dedicated signal detection algorithm, vigiRank for Interactions, has been developed at Uppsala Monitoring Centre.
- Repàs toxicitat CV AINE
- The WEB-RADR project developed three mobile applications (apps) enabling patients, caregivers, and healthcare professionals to report adverse drug reactions (ADRs) and receive up-to-date information and news alerts. UK (Yellow Card) - launched 14 July 2015 Netherlands (LAREB) - launched 29 January 2016 Croatia (HALMED) - launched 18 May 2016 Key features: A convenient alternative to paper or electronic…
- Cal informar les dones en edat fèrtil i que poden estar embarassades dels riscos de l’ús de pregabalina, que l’embaràs ha de ser planificat i que han d’emprar mesures anticonceptives durant el tractament. Sempre s’hauran de ponderar els beneficis i els riscos del tractament i, si cal tractar amb pregabalina durant l’embaràs, es farà a la dosi més baixa possible i fent una supervisió més estricta de la persona. Pregabalin (Lyrica): findings of safety study on risks during pregnancy. Drug Safety Update. Medicines and Healthcare products Regulatory Agency. Published 19 April 2022.
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- 19 (4): e0302300 (2024)
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- 19 (4): e0302205 (2024)
