%0 Journal Article %1 Bekoe2012 %A Bekö, Sándor L. %A Urmann, David %A Lakatos, Andrea %A Glaubitz, Clemens %A Schmidt, Martin U. %D 2012 %I International Union of Crystallography %J Acta Crystallographica Section C %K crystal-structure-determination nimustine solid-state-nmr xrpd %N 3 %P o144--o148 %R 10.1107/s0108270112005252 %T Nimustine hydro\-chloride: the first crystal structure determination of a 2-chloro\-ethyl-N-nitro\-sourea hydro\-chloride derivative by X-ray powder diffraction and solid-state NMR %U http://dx.doi.org/10.1107/s0108270112005252 %V 68 %X Nimustine hydrochloride systematic name: 4-amino-5-(N-(2-chloroethyl)-N-nitrosocarbamoylaminomethyl)-2-methylpyrimidin-1-ium chloride, C9H14ClN6O2+&\#183;Cl&\#18;, is a prodrug of CENU (chloroethylnitrosourea) and is used as a cytostatic agent in cancer therapy. Its crystal structure was determined from laboratory X-ray powder diffraction data. The protonation at an N atom of the pyrimidine ring was established by solid-state NMR spectroscopy.

@article{Bekoe2012, abstract = {Nimustine hydrochloride [systematic name: 4-amino-5-({[N-(2-chloroethyl)-N-nitrosocarbamoyl]amino}methyl)-2-methylpyrimidin-1-ium chloride], C9H14ClN6O2+\&\#183;Cl\&\#18;, is a prodrug of CENU (chloroethylnitrosourea) and is used as a cytostatic agent in cancer therapy. Its crystal structure was determined from laboratory X-ray powder diffraction data. The protonation at an N atom of the pyrimidine ring was established by solid-state NMR spectroscopy.}, added-at = {2019-03-11T21:00:05.000+0100}, author = {Bek{\"{o}}, S{\'{a}}ndor L. and Urmann, David and Lakatos, Andrea and Glaubitz, Clemens and Schmidt, Martin U.}, biburl = {https://www.bibsonomy.org/bibtex/2ee9b67a873a8b0d715c16f16c5632dcc/fairybasslet}, citeulike-article-id = {10385245}, citeulike-linkout-0 = {http://dx.doi.org/10.1107/s0108270112005252}, citeulike-linkout-1 = {http://scripts.iucr.org/cgi-bin/paper?S0108270112005252}, doi = {10.1107/s0108270112005252}, interhash = {b79535e41b72167fa8f9a0cfd342dc78}, intrahash = {ee9b67a873a8b0d715c16f16c5632dcc}, issn = {urn:issn:0108-2701}, journal = {Acta Crystallographica Section C}, keywords = {crystal-structure-determination nimustine solid-state-nmr xrpd}, month = mar, number = 3, pages = {o144--o148}, posted-at = {2013-09-20 14:03:06}, priority = {2}, publisher = {International Union of Crystallography}, timestamp = {2019-03-11T21:06:37.000+0100}, title = {{Nimustine hydro{\-}chloride: the first crystal structure determination of a 2-chloro{\-}ethyl-{\it N}-nitro{\-}sourea hydro{\-}chloride derivative by X-ray powder diffraction and solid-state NMR}}, url = {http://dx.doi.org/10.1107/s0108270112005252}, volume = 68, year = 2012 }