Dysfunction in vital brainstem centers, including those controlling cardiorespiratory- and sleep/arousal pathophysiology, is reported in sudden infant death syndrome (SIDS). Biological mechanisms underlying SIDS, however, remain unclear. Cytokines are inter-cellular signaling chemicals. They can interact with neurotransmitters and might thus modify neural and neuroimmune functions. Cytokines could therefore act as neuromodulators. Interleukin (IL)-2 is a major immune-related cytokine. It has not been previously depicted in vital brainstem centers. We detected intense neuronal IL-2 immune-reactivity in the SIDS brainstem, namely in vital neural centers. This IL-2 overexpression might interfere with neurotransmitters in those critical brainstem centers, causing disturbed homeostatic control of cardiorespiratory and arousal responses, possibly leading to SIDS.
Neuropathology Unit, Department of Anatomic Pathology, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles (U.L.B.), Place van Gehuchten 4, 1020 Brussels, Belgium. Hazim.Kadhim@chu-brugmann.be
%0 Journal Article
%1 Kadhim2010
%A Kadhim, Hazim
%A Deltenre, Paul
%A Prez, Carine De
%A Sebire, Guillaume
%D 2010
%J Neurosci Lett
%K metabolism/pathology;Female;Humans;Infant;Interleukin-2 metabolism;Male;Neuroimmunomodulation;SuddenInfantDeath immunology/pathology BrainStem
%N 2
%P 122--126
%R 10.1016/j.neulet.2010.06.021
%T Interleukin-2 as a neuromodulator possibly implicated in the physiopathology of sudden infant death syndrome.
%U http://dx.doi.org/10.1016/j.neulet.2010.06.021
%V 480
%X Dysfunction in vital brainstem centers, including those controlling cardiorespiratory- and sleep/arousal pathophysiology, is reported in sudden infant death syndrome (SIDS). Biological mechanisms underlying SIDS, however, remain unclear. Cytokines are inter-cellular signaling chemicals. They can interact with neurotransmitters and might thus modify neural and neuroimmune functions. Cytokines could therefore act as neuromodulators. Interleukin (IL)-2 is a major immune-related cytokine. It has not been previously depicted in vital brainstem centers. We detected intense neuronal IL-2 immune-reactivity in the SIDS brainstem, namely in vital neural centers. This IL-2 overexpression might interfere with neurotransmitters in those critical brainstem centers, causing disturbed homeostatic control of cardiorespiratory and arousal responses, possibly leading to SIDS.
@article{Kadhim2010,
abstract = {Dysfunction in vital brainstem centers, including those controlling cardiorespiratory- and sleep/arousal pathophysiology, is reported in sudden infant death syndrome (SIDS). Biological mechanisms underlying SIDS, however, remain unclear. Cytokines are inter-cellular signaling chemicals. They can interact with neurotransmitters and might thus modify neural and neuroimmune functions. Cytokines could therefore act as neuromodulators. Interleukin (IL)-2 is a major immune-related cytokine. It has not been previously depicted in vital brainstem centers. We detected intense neuronal IL-2 immune-reactivity in the SIDS brainstem, namely in vital neural centers. This IL-2 overexpression might interfere with neurotransmitters in those critical brainstem centers, causing disturbed homeostatic control of cardiorespiratory and arousal responses, possibly leading to SIDS.},
added-at = {2011-05-27T21:22:49.000+0200},
author = {Kadhim, Hazim and Deltenre, Paul and Prez, Carine De and Sebire, Guillaume},
biburl = {https://www.bibsonomy.org/bibtex/27dbf11482baaf0e66f6782e66acdc5cb/crc_chus},
doi = {10.1016/j.neulet.2010.06.021},
institution = {Neuropathology Unit, Department of Anatomic Pathology, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles (U.L.B.), Place van Gehuchten 4, 1020 Brussels, Belgium. Hazim.Kadhim@chu-brugmann.be},
interhash = {null},
intrahash = {7dbf11482baaf0e66f6782e66acdc5cb},
journal = {Neurosci Lett},
keywords = {metabolism/pathology;Female;Humans;Infant;Interleukin-2 metabolism;Male;Neuroimmunomodulation;SuddenInfantDeath immunology/pathology BrainStem},
language = {eng},
month = Aug,
number = 2,
pages = {122--126},
pii = {S0304-3940(10)00754-8},
pmid = {20542085},
pst = {ppublish},
timestamp = {2011-05-27T21:22:49.000+0200},
title = {Interleukin-2 as a neuromodulator possibly implicated in the physiopathology of sudden infant death syndrome.},
url = {http://dx.doi.org/10.1016/j.neulet.2010.06.021},
volume = 480,
year = 2010
}