The inclusion compound (IC) of cyclodextrin (CD) containing the antitumor drug Methotrexate (MTX) as a guest molecule was obtained to increase the solubility of MTX and decrease its inherent toxic effects in nonspecific cells. The IC was conjugated with gold nanoparticles (AuNPs), obtained by a chemical method, creating a ternary intelligent delivery system for MTX molecules, based on the plasmonic properties of the AuNPs. Irradiation of the ternary system, with a laser wavelength tunable with the corresponding surface plasmon of AuNPs, causes local energy dissipation, producing the controlled release of the guest from CD cavities. Finally, cell viability was evaluated using MTS assays for beta-CD/MTX and AuNPs + beta-CD/MTX samples, with and without irradiation, against HeLa tumor cells. The irradiated sample of the ternary system AuNPs + beta-CD/MTX produced a diminution in cell viability attributed to the photothermal release of MTX.
%0 Journal Article
%1 RN392
%A Silva, N.
%A Riveros, A.
%A Yutronic, N.
%A Lang, E.
%A Chornik, B.
%A Guerrero, S.
%A Samitier, J.
%A Jara, P.
%A Kogan, M.J.
%D 2018
%J Nanomaterials
%K binding, citrate complex, compound, cyclodextrin, delivery delivery, dqcauchile gold hepatotoxicity, inclusion irradiation, laser, methotrexate, nanoparticles, oxidative photothermal release, stabilization, stress, system, therapy,
%N 12
%R 10.3390/nano8120985
%T Photothermally Controlled Methotrexate Release System Using Beta-Cyclodextrin and Gold Nanoparticles
%U /brokenurl#<Go to ISI>://WOS:000455323100023
%V 8
%X The inclusion compound (IC) of cyclodextrin (CD) containing the antitumor drug Methotrexate (MTX) as a guest molecule was obtained to increase the solubility of MTX and decrease its inherent toxic effects in nonspecific cells. The IC was conjugated with gold nanoparticles (AuNPs), obtained by a chemical method, creating a ternary intelligent delivery system for MTX molecules, based on the plasmonic properties of the AuNPs. Irradiation of the ternary system, with a laser wavelength tunable with the corresponding surface plasmon of AuNPs, causes local energy dissipation, producing the controlled release of the guest from CD cavities. Finally, cell viability was evaluated using MTS assays for beta-CD/MTX and AuNPs + beta-CD/MTX samples, with and without irradiation, against HeLa tumor cells. The irradiated sample of the ternary system AuNPs + beta-CD/MTX produced a diminution in cell viability attributed to the photothermal release of MTX.
@article{RN392,
abstract = {The inclusion compound (IC) of cyclodextrin (CD) containing the antitumor drug Methotrexate (MTX) as a guest molecule was obtained to increase the solubility of MTX and decrease its inherent toxic effects in nonspecific cells. The IC was conjugated with gold nanoparticles (AuNPs), obtained by a chemical method, creating a ternary intelligent delivery system for MTX molecules, based on the plasmonic properties of the AuNPs. Irradiation of the ternary system, with a laser wavelength tunable with the corresponding surface plasmon of AuNPs, causes local energy dissipation, producing the controlled release of the guest from CD cavities. Finally, cell viability was evaluated using MTS assays for beta-CD/MTX and AuNPs + beta-CD/MTX samples, with and without irradiation, against HeLa tumor cells. The irradiated sample of the ternary system AuNPs + beta-CD/MTX produced a diminution in cell viability attributed to the photothermal release of MTX.},
added-at = {2019-12-04T03:57:35.000+0100},
author = {Silva, N. and Riveros, A. and Yutronic, N. and Lang, E. and Chornik, B. and Guerrero, S. and Samitier, J. and Jara, P. and Kogan, M.J.},
biburl = {https://www.bibsonomy.org/bibtex/20994afd5e1b5e6d67b90b23749af615d/dqcauchile},
doi = {10.3390/nano8120985},
interhash = {d5b57de6ab68d82990aa080ce2d8cb50},
intrahash = {0994afd5e1b5e6d67b90b23749af615d},
issn = {2079-4991},
journal = {Nanomaterials},
keywords = {binding, citrate complex, compound, cyclodextrin, delivery delivery, dqcauchile gold hepatotoxicity, inclusion irradiation, laser, methotrexate, nanoparticles, oxidative photothermal release, stabilization, stress, system, therapy,},
number = 12,
timestamp = {2019-12-04T03:58:17.000+0100},
title = {Photothermally Controlled Methotrexate Release System Using Beta-Cyclodextrin and Gold Nanoparticles},
type = {Journal Article},
url = {/brokenurl#<Go to ISI>://WOS:000455323100023},
volume = 8,
year = 2018
}